Urate from purines, tissue acids, and purine synthesis can lead to overproduction and under-exretion of uric acid
Hyperuricemia is the result of this process
Hyperuricemia can lead to Gout, Kidney Disease, Cardiovascular Disease, and even death
What is Hyperuricemia?
Is Hyperuricemia Dangerous?
In short -- Yes. Hyperuricemia can put you at risk for a host of serious health conditions including metabolic syndrome, abnormal glucose, dyslipidemia, abnormal blood pressure, Gout, kidney disease, obesity, and more.
Hyperuricemia is an abnormally elevated blood level of uric acid. Overproduction and under-excretion of uric acid can stem from a host of causes. While uric acid is a product of the breakdown of purines from the food we eat, this is a rather minute portion of the contribution to the body. The majority of uric acid production stems from the dying cells in our body. Addressing the rate at which this is taking place can drastically alter these levels.
Some factors that contribute to Hyperuricemia include genetics, diet, weight/obesity, alcohol intake, hypertension, insulin resistance, kidney insufficiency, thyroid problems, and prescription medications such as diuretics.
The causes of hyperuricemia are often divided between over-production (mostly metabolic causes) and under-excretion (mainly renal). Asymptomatic hyperuricemia can be present without the threat of Gout attacks, however, in most cases of Gout the combination of both causes are more common. Many believe that a purine-rich diet is a major cause of hyperuricemia. The actual purines only exacerbate this condition and are not sufficient enough to claim as an actual cause. However, when you incorporate how our general diet and lifestyle affects the cells of our body, and the rate at which they die-off, we can begin to understand how important this area remains as a factor of this condition.
The hypothesis that asymptomatic hyperuricemia mediates cardiovascular disease has been shown to be true according to several studies. Many studies have demonstrated that serum uric acid was an independent predictor of hypertension, both primary and renal hypertension. The data has suggested that both types can result from lessened renal excretion of urate. In the presence of hypertensive disease it is thought that the altered lactic acid metabolism could also alter the transport of uric acid. In addition to hypertension, serum urate levels have also been shown as independent predictors of cardiovascular disease, cardiac arrest, stroke and kidney disease. The rise in organ transplantation, namely kidney and liver, is also a contributor to the higher presence of hyperuricemia today.
Secondary Gout can be caused by a wide variety of conditions that increase our cell's turnover rate. These risk factors include anemia, alcoholism, obesity and prescription drugs. These are all known to cause both over-production and under-excretion of uric acid. A number of prescription drugs are said to contribute to this condition, including low-dose aspirin and diuretics to name a few.
The majority of Gout patients have this initial stage of asymptomatic hyperuricemia and often goes unrecognized for decades. The scary part of this is knowing how this condition can foster the development of more serious medical ailments associated with Gout. Many will never even have an attack. In fact, one study showed that only 12% of patients with urate levels between 7.0 and 7.9mg/dl developed Gout. However, patients with 9.0mg/dl and above had a much greater likelihood, by six-fold in fact, of advancing to clinical Gout.
See the evaluation form below. Take the time to fill this out and a nutritional specialist can provide you a full assessment of what you may be doing to contribute to this condition and how to help.
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