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Daily probiotic improves acne-prone skin

12 January, 2018

Working at a genetic level

In a recent pilot study, published in the journal Beneficial Microbes, researchers followed two small groups of people over a 12-week period

One consumed a liquid supplement (75mg/day) containing Lactobacillus rhamnosus​ SP1 (LSP1) at a dose of 3 billion ​colony forming units (CFU) per day. A placebo group of 10 subjects received a liquid containing no probiotics.

The choice to study LSP1 was based on previous evidence​​ identifying the strainís effectiveness in improving leaky gut/dysbiosis.

Skin biopsies taken at the beginning and end of the study period were analyzed for two things: the gene expression of insulin-like growth factor 1 (IGF1​) and forkhead box protein O1 (FOXO1​).

Based on physicians using a standard five-point scale for rating improvement in skin appearance, those taking the probiotic were 28% more likely to be improved/markedly improved (versus worsened or unchanged) compared with the placebo group.

A gut-skin axis?

The probiotic group in addition showed a 32% reduction and a 65% increase in IGF1 and FOXO1 gene expression in the skin, respectively. Gene expression is the way genes function to switch certain body functions, such as hormones, on or off.

This, say the scientists, shows that that supplementation with LSP1 was able to normalizes skin expression of genes involved in insulin signaling and improves the appearance of adult acne.

"It is possible that this probiotic strain may improve insulin resistance through direct metabolic effects and/or by correcting a state of intestinal dysbiosis,"​ the study's authors theorized.

"Alterations in the gut microbiome and gut permeability can increase levels of circulating toxin that in turn activate proteins (TLR-2 and TLR-4) that play a key role in the innate immune system. Their activation can induce the release of cell-signaling molecules and the expression of enzymes that ultimately aggravate acne."​

According to the authors, the effect of the probiotics on gene expression in the skin, which needs to be confirmed by other studies, suggests the existence of a gut-skin axis (similar to the well-established gut-brain axis) in which skin physiology is affected by specific bacterial strains in the gastrointestinal tract.

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      • 1 cup quinoa, rinsed
      • 2 cups water
      • 1 package (6 ounces) fresh  organic baby spinach, torn
      • 1/2 cup dried cranberries
      • DRESSING:
      • 3 tablespoons olive oil
      • 2 tablespoons orange juice
      • 1 tablespoon red wine vinegar
      • 1 tablespoon maple syrup
      • 1 garlic clove, minced
      • 1/2 teaspoon Himalayan Salt
      • 1/8 teaspoon pepper
      • 1 green onion, finely chopped
      • 1/2 cup chopped pecans, toasted
        1. DIRECTIONS

          In a small saucepan, bring quinoa and water to a boil. Reduce heat; cover and simmer for 12-15 minutes or until water is absorbed. Remove from the heat; fluff with a fork. Cover and let stand for 10 minutes.
          In a large bowl, combine the warm quinoa, spinach and cranberries. For dressing, in a small bowl, whisk the oil, orange juice, vinegar, maple syrup, garlic, salt and pepper. Stir in onion. Pour over quinoa mixture; toss to coat. Sprinkle with pecans.Yield: 10 servings.
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