Higher levels of meat and seafood consumption are associated with an increased risk of Gout, whereas a higher level of consumption of dairy products is associated with a decreased risk.
Moderate intake of purine-rich vegetables or protein is not associated with an increased risk of gout.
Increased uric acid production and decreased uric acid excretion have both been implicated in the pathogenesis of alcohol-induced hyperuricemia.
Purine Amounts in Popular Food/Drinks:
Beef / Steak: High Purine
Seafood: High Purine
Asparagus & Spinach: Moderate to Moderately High Purine
Beer: Moderate to High Purine
Sugar: Very low / non-existent
Liquor and Wine: ZERO purines
Low to no purines in sugar?
Low to no purines in liquor or wine?
Sugar/Alcohol = Good for Gout??
Protein = Bad??
Gout Diet- Gout Foods- Purines- Gout Food List - Uric Acid - Foods to Avoid with Gout
The information to the left raises some serious questions about our obsession with trying to control Gout with low-purine diets.
- Purines are the main culprit? Yet, study after study fails to provide any evidence that high-purine vegetables have any negative impact on the Gout sufferer.......
- Then there's the all mighty fact that dietary purines only equate to roughly 30% of our total uric acid production. If the other whopping 70% stems from other sources, is it safe to say that we need to focus our attention elsewhere?
It might be best that we take a closer look at the general patterns of eating habits and lifestyles, rather than focus on a specific purine source. Our focus needs to shift from uric acid producers, to excretion inhibitors. Uric acid excretion - rather lack thereof - is a much larger part of the problem.
- Considering red-meat has been so demonized, it might be safe to assume those that consume meat in large quantities aren't likely to be consuming dark-green veggies in the same proportion. In other words, are large red-meat eaters our most "health-conscious" bunch? Would it then be safe to assume this eating style also consumes breads and sugary foods in larger quantities? Sodas and fried foods coupled with that steak dinner? More processed food in general? Maybe beer and alcohol, as well? How about other bad habits? Lack of exercise? Obesity? Reduced water intake?
This could explain why high-purine dark greens have no effect on Gout, whereas red-meat does. It seems logical that eating and lifestyle patterns are more important than solely focusing on those pesky purines.
Uric Acid Excretion Inhibitors:
-Sugar/Fructose: Large amounts, more than 25g/day, causes both an increase in uric and production, and a decrease in excretion. Gout is strongly associated with diabetes and metabolic syndrome. This indicates the likelihood of a blood sugar connection. Insulin resistance contributes to hyperuricemia, and hyperuricemia induces insulin resistance. This culprit is a double whammy.
- Alcohol: Metabolically behaves like Fructose, dehydrates the blood leaving more room to "fill up" with uric acid, can produce excess uric acid, and weighs on the kidney/liver filtration thereby reducing excretion. QUADRUPLE THREAT!
- Dehydration: When your body is dehydrated, uric acid levels rise and your kidney's ability to excrete excess uric acid is drastically reduced. Dehydration also reduces healthy bowel movements. Am I drinking enough water?
- Constipation: Close to 30% of uric acid elimination takes place through waste removal. Constipation greatly reduces uric acid excretion. Digestive system issues can lead to severe imbalances that directly affect your health and gout control. Close to 70% of the immune system resides the digestive tract. Healthy bacteria balance is essential.
- Excess weight/Obesity: Excess body fat weighs on every major organ and system of the body. Healthy, functioning bodily systems are essential to uric acid excretion.
- Prescription Drugs: All prescription medications negatively affect the major systems of the body one way or another. Uric acid excretion is reduced when these systems have to focus on outside invaders/toxins such as drugs. The principal drugs that contribute to hyperuricemia by decreased excretion are the primary antiuricosurics. Other drugs and agents include diuretics, salicylates, pyrazinamide, ethambutol, nicotinic acid, ciclosporin, 2-ethylamino-1,3,4-thiadiazole, and cytotoxic agents.
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