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Key Points About
Indomethacin (Indocin):


  • Indomethacin is a non-steroidal
    anti-inflammatory prescribed for gout
    and other forms of arthritis

  • Indomethacin can reduce
    horomones that cause inflammation
    and pain

  • Indomethacin can cause
    intestinal bleeding, which can be fatal.

  • Patients with liver or kidney
    disease, heart disease, stomach ulcers,
    or other serious health conditions
    should consider other Gout
    treatment options

  • Indomethacin can cause
    serious side effects that should be
    discussed with your doctor




  • Is Indomethacin (Indocin/Indocid) a Safe and Effective Gout Treatment?




    indomethacin



    INDOMETHACIN (Indocin/Indocid) is a non-steroidal anti-inflammatory drug (NSAID) used to treat the inflammation caused by Gout, and other medical conditions such as bursitis, arthritis, and ankylosing spondylitis. This drug sets out to block certain hormone-like molecules called prostaglandins from releasing the substances that cause inflammation. Indomethacin cannot lower the uric acid in the body, therefore is incapable of altering the progressive course of these conditions. Indomethacin is simply a temporary fix to address the symptoms of inflammation including fever, pain, swelling, and stiffness.

    NSAIDs have become the treatment of choice among Doctors and Indomethacin is the most widely used prescription drug for most gout attacks. NSAID's may also have significant toxicity, but if used for the SHORT TERM, they are generally well tolerated. Possible side effects include fatigue, dizziness, indigestion, constipation, nausea, vomiting, headache, sleepiness, depression, and ringing in the ears.

    Other NSAIDs include Ibuprofen (Motrin/Advil), Aspirin, Naproxen (Aleve), Celebrex, and Diclofenac. The over-the-counter options can be very dangerous. Many people take them far too often due to their easy access and assumed saftey. It is very important to understand potential side effects and drug interactions. NSAIDs can be very hard on the stomach, liver, and kidneys. "Popping" them at a moment's notice, too often, can have grave consequences.

    Possible drug interactions include:

  • Over-the-counter NSAIDs including Advil, Aleve, and Motrin
  • Prescription NSAIDs, such as diflunisal (Dolobid) and naproxen (Naprosyn)
  • Aspirin
  • Angiotensin-converting enzyme (ACE) inhibitors for high blood pressure such as benazepril (Lotensin), captopril (Capoten), and enalapril (Vasotec)
  • Beta blockers for high blood pressure, including atenolol (Tenormin), labetalol (Normodyne), and metoprolol (Lopressor, Toprol XL)
  • Angiotensin receptor blockers (ARBs) for high blood pressure, such as candesartan (Atacand), eprosartan (Teveten), and irbesartan (Avapro)
  • Oral corticosteroids such as dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone)
  • Drugs used to treat rheumatoid arthritis, including methotrexate (Rheumatrex)
  • Diuretics (water pills) such as triamterene (Dyrenium, in Dyazide)
  • Blood thinners such as warfarin (Coumadin)
  • The cardiac drug digoxin (Lanoxin)
  • The bipolar disorder drug lithium (Eskalith, Lithobid)
  • The gout treatment probenecid (Benemid)
  • The seizure medication phenytoin (Dilantin)


  • Indomethacin can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Even people without heart disease or risk factors could have a stroke or heart attack while taking this medicine.

    Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

    Indomethacin may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using indomethacin, especially in older adults.

    You should not use indomethacin if you are allergic to it, or if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID.



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