Iron and Gout/
Iron is critical in
nearly all cell functions.
Abnormal iron homeostasis
is found in almost all
Rheumatic and Gout cases.
Iron supplementation must
be carefully evaluated as it
can have a negative impact
on a number of chronic
Does Iron Cause Problems for People with Gout and Arthritis?
Study after study has shown a link between iron homeostasis and painful inflammatory conditions such as Gout and Rheumatoid Arthritis. Oddly enough, both iron overload and anemic levels seem to yield a significant impact on uric acid and inflammatory cytokines involved in rheumatic cases.
Hemochromatosis (iron overload) generally stems from genes inherited from your parents, hereditary hemochromatosis. One may also obtain this condition from conditions such as liver disease or repetitive blood transfusions. The body cannot increase its natural excretion ability. Therefore, anyone with this iron overload condition continue to store and accumulate the excess. These deposits are stored in the joints, the heart, the liver, and even in the testicles where damage can ensue. Many live with this condition unbeknownst to them bearing no signs or symptoms. Others can suffer terribly with more severe symptoms including fatigue, joint pain, sexual dysfunction, diabetes, liver cirrhosis, and even heart failure. Women accumulate iron slower than men as they are able to excrete more through menstruation and breastfeeding. This can delay symptoms of organ damage stemming from this iron overload by approximately 10 more years than men.
Conversely, iron deficiency still seems to play an intimate role in our body's inflammatory response. Iron levels must be firmly regulated to ensure oxygen delivery, metabolism and redox management while protecting us from toxins that cause cellular damage and death. This balance is extremely delicate and directly tied to cell health, as well as inflammatory and infection responses. Chronic inflammatory diseases are deeply influenced by iron status.
Additionally, chronic inflammation and inflammatory diseases can actually cause anemia. Long-term and chronic conditions can affect the body's ability to produce healthy red blood cells. Anemia of inflammation is the second most well known cause, next to iron deficiency anemia. Conditions that tend to cause anemia of inflammation include chronic infections such as tuberculosis, autoimmune conditions or diseases with inflammation, and certain types of Cancer like Hodgkin's, lung, and breast cancer. Symptoms of this condition can be difficult to detect or differ from the primary condition that is causing the anemia. As a secondary condition, it is often undetected, undiagnosed, and therefore untreated.
While we have identified both Anemia and Hemochromatosis as direct risks for Gout, Rheumatism, and other chronic conditions such as Diabetes and Obesity -- the biological mechanisms remain poorly understood.
Here are some things we do know:
Elevated levels of uric acid are associated with elevated iron levels.
Anemia has been identified as a novel risk for Gout.
Under chronic inflammatory conditions cytokines induce a diversion of iron traffic.
Iron homeostasis is altered in rheumatic diseases, with decreased metal in response to inflammation.
Iron supplementation could potentially have a negative impact on the activity of the involved chronic conditions.
Vitamin C enhances iron absorption. As a result, Vitamin C can bond to Uric Acid in the blood and make it nearly impossible to excrete it from the body as needed.
Cytokine-mediated regulation of iron transport in human monocytic cells
Connection With High Iron in Blood for Gout
Iron homoeostasis in rheumatic disease
Anemia and the onset of gout in a population-based cohort of adults: Atherosclerosis Risk in Communities study
Uric Acid as a Potential Cue to Screen for Iron Overload
Near-iron deficiency-induced remission of gouty arthritis
Are you aware that uncontrolled inflammation can lead to
Heart Disease, Diabetes, and even Cancer?
You must remove chronic inflammation from your life
before the inflammation removes the life out of you!
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