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1) Uric Acid Crystals can take a long time (months or years) to accumulate, most commonly in connective tissues in and around joints, especially in the lower limbs. During this period there may well be no symptoms whatsoever. About 95% of people with hyperuricemia, high uric acid in the blood supply, will not have a gout attack throughout their entire lives. However, they may experience pain and discomfort from crystallized uric acid in their joints. Pain in the heel/achilles tendon is very common. Sometimes uric acid problems are even misdiagnosed as Rheumatoid Arthritis. The uric acid crystals will cut into the synovial fluid sacks that cushion all joints releasing this fluid into the blood. This can cause blood readings to indicate Rheumatoid Arthritis when, in fact, the problem is really uric acid crystals.
2) A single joint is almost always involved in the initial episodes of an acute attack, most commonly starting with the big toe. This involves local irritation and aching with the tissues becoming swollen, red, hot, shiny and excessively painful. The pain is frequently described as the worst ever experienced.
3) There are periods between attacks. Some never experience another attack, or perhaps at least not for several years. However, for the majority, a second attack occurs within a year. The frequency, severity, and number of joints involved is highly likely to increase over time. This progression eventually leads to joint damage and chronic pain over an average of about 10 years.
4) Chronic tophaceous gout large crystal deposits, or tophi, produce irregular firm nodules, predominantly around the upper surfaces of the fingers and hands. They can form in other places as well, including forearms, achilles tendon, and/or the ears. When left untreated, these can lead to severe deformity.
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Uric acid problems do not manifest themselves overnight. They ensue after years of excess uric acid production coupled with limited excretion. Each time your system has produced even a little more than it secreted, is actually leading up to your first attack. If we do not bring the system back down to a manageable level, new attacks are inevitable and can become more frequent and severe over time.
The soluble uric acid measured in your blood supply has little to do with the uric acid that has become crystallized and is now residing in connective tissue. This uric acid cannot be measured. These crystals are always there in a solid form, "melting" when the levels in the blood will allow, and adding to the build up when levels in the blood become too high for the blood to carry. These deposits are what migrate into the joint causing the acute gout attack. When the tissue is full, and your food indulgences produce more uric acid than the blood can hold, the uric acid starts to crystallize between bone joints.
Visualize the uric acid metabolic process as a 16-ounce glass. Let's assume that when you are young, your glass contains about 6oz. Let us consider that at a 16oz level, you would be destined for a gout attack. After years of splurging on high purine and acidic food selections, your glass gradually rises to 14oz. An average meal in purines may bring you up to 15.5, but luckily, within 4-6 hours your system can bring it back down to 14.1. This process is repeated several times, until one day you top the 16 ounces, and you are now in a gout attack.
With an initial cleansing diet, water, and GC®, we can successfully bring that glass down to a sustainable level. It may never revert back to a low 6oz, but at least at 8oz we can manage the uric acid levels and avoid future gout attacks. This is the main reason for recommending an initial strict diet. You can allow the GC® herbs and your body to go straight to work without an abundance of new acid formations to slow you down. GC® will also be 'melting' your stored uric acid at such high rates, any additional uric acid added to the blood supply can cause the blood to become hyper-saturated. If your body is unable to expel these excessive amounts quickly enough, the kidneys are likely to reclaim and recycle right back through the joints again. This process could result in new deposits into other joints or cause the current attack to worsen. This 'melting' of old stored uric acid is also the logic behind consuming large amounts of non-chlorinated water. Proper hydration is imperative to flush the newly dissolved uric acid out of your blood supply and past the kidneys.
It is also important to maintain your body weight during a gout attack. All body cells contain purines. In fact, 70% of all uric acid creation stems from the cellular level. Fat cells, where weight loss begins, contain copious amounts of purines. Thus, weight loss increases uric acid production in large amounts, over-taxing your already overloaded system, causing the attack to be prolonged.
Humans excrete a nitrogenous waste, uric acid. It is the product of nucleic acid, not a protein of the metabolism.
Uric acid is the end metabolism product of purine, purine being the nitrogen-containing compound that occurs in nucleic acid. Confusion arises between the purine and protein, but they're a dissimilar chemical structure entirely. Even so, most foods that contain protein, also possess purines.
Uric acid is only slightly soluble in water and may precipitate out of solution contributing to the formation of kidney stones. Uric acid may also procure needle-like crystals in one or more joints, producing the excruciating pain of an acute gout attack.
Curiously, our kidneys reclaim most of the uric acid filtered at the glomeruli. Why, if it can cause problems? Uric acid is a potent antioxidant and can protect cells from DNA damage. In our blood, for example, uric acid serves as an antioxidant and helps prevent damage to our blood vessel linings. As a result, a continual supply of uric acid is important for protecting our blood vessels.
Below you'll find a very interesting article presented as "new information" regarding Uric Acid and Alzheimer's protection. Funny thing is, for years we've preached about the importance of uric acid as an essential DNA protector. We've always feared the use of prescription drugs, such as Allopurinol, which unnaturally attempts to suppress uric acid production altogether. Uric acid has a role in protecting DNA from single-strand breaks caused by free radicals in the body leading to a protective effect in neurodegenerative diseases. The brain is particularly vulnerable to oxidative stress as it is considered an 'expensive tissue' with a particularly high metabolic rate and comparatively increased utilization of oxygen. Brain tissue is also high in unsaturated lipids, which makes it more susceptible to free radical damage. Oxidative stress is thus linked to the pathogenesis of neurodegenerative diseases and also ischemic brain injury. While an overabundance can be dangerous in many ways, we still require proper levels of Uric Acid production.
People who suffer with gout commonly overproduce uric acid or under excrete it. In extreme cases, a person may fall into both categories, causing severe gout attacks repeatedly. Blood serum testing will not show the amount of uric acid crystallized in connective tissue. This insoluble amount is the culprit ready to incite the next acute attack.
Our herbal blend, GC® GoutCare, helps the body regulate this process and aid to maintain a healthy level of uric acid in the blood. The herbs combine with the uric acid to help it remain soluble. With just a small change in the diet, a person will be able to eat a complete variety of foods and still remain gout free.
Thought I would share 'my story'. I have been a longtime sufferer of gout. First diagnosed when I was 22, I have dealt with it every winter for the past 17 years. It has gradually gotten worse, to the point where the medications (which I hated to take) weren't as effective.
I ordered goutcare and have taken it for the last 2 months. I haven't had one attack and not only that I have noticed areas where I had 'aches' and stiffness start to loosen up and become more flexible. I am and avid jogger/runner and last summer literally could only run once every 3 days because my right ankle needed that much time to recover. When I did run, sometimes I would get a sharp pain in the joint area for no apparent reason that I knew of.
Now, I am starting to run every day again and am feeling increased mobility and no pain or stiffness at all. I feel like I have new ankles!
Thanks for working with me and providing a great product! I no longer will be worrying about painful gout attacks!
David J Swanson Jr
Dear Smith & Smith Enterprises,
I had been on way too many prescriptions and nothing worked but prednisone. Colcrys (replacement for Colchicine) two times a day with 10mg Prednisone daily for months. I was on Allopurinol for at least one year then to Uloric for over a year then Probenecid later and none really helped.
I was getting a gout flare up about every three weeks. Finally, after reading everything I could find and information from your site, I put two and two together. My doctor had suggested that I take two baby asprin daily and 21 almonds daily for the good fat intake both for heart health. I think somewhere in your site I read that asprin and roasted nuts could increase uric acid. I stopped both and after a few months my gout flare up was reduced frequency.
During all this time my liver enzymes were over 5 times elevated so my Dr. was doing regular blood work. He took me off everything and introduced different drugs at a time. During this he added back the Gout Cure and then did a follow up and my uric acid was way low normal, something like 2.5. I have been off gout Cure for about one month as I ran out, and with all the liver concerns I am not even taking a asprin or vitamin. I went in for blood work last week and my physical and my uric acid level is almost 9. My doctor told me to get back on GC NOW! He has also contacted me for the link to suggest other patients get on this, so that is good news for GC!