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Iron and Gout/
Arthritis Connections:


  • Iron is critical in
    nearly all cell functions.

  • Abnormal iron homeostasis
    is found in almost all
    Rheumatic and Gout cases.

  • Iron supplementation must
    be carefully evaluated as it
    can have a negative impact
    on a number of chronic
    health conditions.




  • Does Iron Cause Problems for People with Gout and Arthritis?









    Study after study has shown a link between iron homeostasis and painful inflammatory conditions such as Gout and Rheumatoid Arthritis. Oddly enough, both iron overload and anemic levels seem to yield a significant impact on uric acid and inflammatory cytokines involved in rheumatic cases.


    While we have identified both Anemia and Hemochromatosis as direct risks for Gout, Rheumatism, and other chronic conditions such as Diabetes and Obesity -- the biological mechanisms remain poorly understood.


    Here are some things we do know:

  • Elevated levels of uric acid are associated with elevated iron levels.

  • Anemia has been identified as a novel risk for Gout.

  • Under chronic inflammatory conditions cytokines induce a diversion of iron traffic.

  • Iron homeostasis is altered in rheumatic diseases, with decreased metal in response to inflammation.

  • Iron supplementation could potentially have a negative impact on the activity of the involved chronic conditions.

  • Vitamin C enhances iron absorption. As a result, Vitamin C can bond to Uric Acid in the blood and make it nearly impossible to excrete it from the body as needed.



  • Learn More:


    Cytokine-mediated regulation of iron transport in human monocytic cells


    Connection With High Iron in Blood for Gout


    Iron homoeostasis in rheumatic disease


    Anemia and the onset of gout in a population-based cohort of adults: Atherosclerosis Risk in Communities study


    Uric Acid as a Potential Cue to Screen for Iron Overload


    Near-iron deficiency-induced remission of gouty arthritis










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